Don't see why Destro builds would talent into Suppression at all. Why? 4% is your miss chance against a level 60 target, and 3% is hit cap because the 1% unmitigatable resist chance counts vs. players too. Suppression only helps for Aff spells, and since you're spamming Destro spells, you need to hit cap from gear anyway. Therefore, Suppression is a waste of 2 talent points.